Accelerometer-measured physical activity patterns are associated with phenotypic age: Isotemporal substitution effects

Prolonged sitting appears to accelerate aging, while optimal physical activity patterns have been found delay the process. It is an emerging topic, and no conclusions reached regarding relationship between biomarkers-measured aging. Hence, aim of this study was investigate association sensor-based objectively measured phenotypic age using a nationwide population from National Health Nutrition Examination Survey (NHANES) in United States. Weighted linear regression models were performed evaluate sedentary behavior, light-intensity (LPA), moderate-to-vigorous (MVPA) age. A total 6439 eligible participants included weighted respondents 49,964,300. Results showed that prolonged positively associated with fully adjusted model [β (95% CI): 0.009(0.007,0.011), p < 0.001], increasing volume LPA MVPA younger −0.010(-0.013,-0.006), 0.001; −0.062(-0.075,-0.048), 0.001]. By utilizing Isotemporal Substitution Model, it replacing 30 minutes behavior or per day estimated 0.4 1.9 years reduction. According study's findings, maintaining certain level could process aging intensity matters.